Developing a Neural Network for Cancer Survival Dataset

It can be challenging to develop a neural network predictive model for a new dataset.

One approach is to first inspect the dataset and develop ideas for what models might work, then explore the learning dynamics of simple models on the dataset, then finally develop and tune a model for the dataset with a robust test harness.

This process can be used to develop effective neural network models for classification and regression predictive modeling problems.

In this tutorial, you will discover how to develop a Multilayer Perceptron neural network model for the cancer survival binary classification dataset.

After completing this tutorial, you will know:

  • How to load and summarize the cancer survival dataset and use the results to suggest data preparations and model configurations to use.
  • How to explore the learning dynamics of simple MLP models on the dataset.
  • How to develop robust estimates of model performance, tune model performance and make predictions on new data.

Let’s get started.

Tutorial Overview

This tutorial is divided into 4 parts; they are:

  1. Haberman Breast Cancer Survival Dataset
  2. Neural Network Learning Dynamics
  3. Robust Model Evaluation
  4. Final Model and Make Predictions

Haberman Breast Cancer Survival Dataset

The first step is to define and explore the dataset.

We will be working with the “haberman” standard binary classification dataset.

The dataset describes breast cancer patient data and the outcome is patient survival. Specifically whether the patient survived for five years or longer, or whether the patient did not survive.

This is a standard dataset used in the study of imbalanced classification. According to the dataset description, the operations were conducted between 1958 and 1970 at the University of Chicago’s Billings Hospital.

There are 306 examples in the dataset, and there are 3 input variables; they are:

  • The age of the patient at the time of the operation.
  • The two-digit year of the operation.
  • The number of “positive axillary nodes” detected, a measure of whether cancer has spread.

As such, we have no control over the selection of cases that make up the dataset or features to use in those cases, other than what is available in the dataset.

Although the dataset describes breast cancer patient survival, given the small dataset size and the fact the data is based on breast cancer diagnosis and operations many decades ago, any models built on this dataset are not expected to generalize.

Note: to be crystal clear, we are NOT “solving breast cancer“. We are exploring a standard classification dataset.

Below is a sample of the first 5 rows of the dataset

30,64,1,1
30,62,3,1
30,65,0,1
31,59,2,1
31,65,4,1
...

You can learn more about the dataset here:

We can load the dataset as a pandas DataFrame directly from the URL; for example:

Running the example loads the dataset directly from the URL and reports the shape of the dataset.

In this case, we can confirm that the dataset has 4 variables (3 input and one output) and that the dataset has 306 rows of data.

This is not many rows of data for a neural network and suggests that a small network, perhaps with regularization, would be appropriate.

It also suggests that using k-fold cross-validation would be a good idea given that it will give a more reliable estimate of model performance than a train/test split and because a single model will fit in seconds instead of hours or days with the largest datasets.

Next, we can learn more about the dataset by looking at summary statistics and a plot of the data.

Running the example first loads the data before and then prints summary statistics for each variable.

We can see that values vary with different means and standard deviations, perhaps some normalization or standardization would be required prior to modeling.

A histogram plot is then created for each variable.

We can see that perhaps the first variable has a Gaussian-like distribution and the next two input variables may have an exponential distribution.

We may have some benefit in using a power transform on each variable in order to make the probability distribution less skewed which will likely improve model performance.

Histograms of the Haberman Breast Cancer Survival Classification Dataset

We can see some skew in the distribution of examples between the two classes, meaning that the classification problem is not balanced. It is imbalanced.

It may be helpful to know how imbalanced the dataset actually is.

We can use the Counter object to count the number of examples in each class, then use those counts to summarize the distribution.

The complete example is listed below.

Running the example summarizes the class distribution for the dataset.

We can see that class 1 for survival has the most examples at 225, or about 74 percent of the dataset. We can see class 2 for non-survival has fewer examples at 81, or about 26 percent of the dataset.

The class distribution is skewed, but it is not severely imbalanced.

This is helpful because if we use classification accuracy, then any model that achieves an accuracy less than about 73.5% does not have skill on this dataset.

Now that we are familiar with the dataset, let’s explore how we might develop a neural network model.

Neural Network Learning Dynamics

We will develop a Multilayer Perceptron (MLP) model for the dataset using TensorFlow.

We cannot know what model architecture of learning hyperparameters would be good or best for this dataset, so we must experiment and discover what works well.

Given that the dataset is small, a small batch size is probably a good idea, e.g. 16 or 32 rows. Using the Adam version of stochastic gradient descent is a good idea when getting started as it will automatically adapt the learning rate and works well on most datasets.

Before we evaluate models in earnest, it is a good idea to review the learning dynamics and tune the model architecture and learning configuration until we have stable learning dynamics, then look at getting the most out of the model.

We can do this by using a simple train/test split of the data and review plots of the learning curves. This will help us see if we are over-learning or under-learning; then we can adapt the configuration accordingly.

First, we must ensure all input variables are floating-point values and encode the target label as integer values 0 and 1.

Next, we can split the dataset into input and output variables, then into 67/33 train and test sets.

We must ensure that the split is stratified by the class ensuring that the train and test sets have the same distribution of class labels as the main dataset.

We can define a minimal MLP model. In this case, we will use one hidden layer with 10 nodes and one output layer (chosen arbitrarily). We will use the ReLU activation function in the hidden layer and the “he_normal” weight initialization, as together, they are a good practice.

The output of the model is a sigmoid activation for binary classification and we will minimize binary cross-entropy loss.

...
# determine the number of input features
n_features = X.shape[1]
# define model
model = Sequential()
model.add(Dense(10, activation='relu', kernel_initializer='he_normal', input_shape=(n_features,)))
model.add(Dense(1, activation='sigmoid'))
# compile the model
model.compile(optimizer='adam', loss='binary_crossentropy')

We will fit the model for 200 training epochs (chosen arbitrarily) with a batch size of 16 because it is a small dataset.

We are fitting the model on raw data, which we think might be a good idea, but it is an important starting point.

At the end of training, we will evaluate the model’s performance on the test dataset and report performance as the classification accuracy.

Finally, we will plot learning curves of the cross-entropy loss on the train and test sets during training.

Tying this all together, the complete example of evaluating our first MLP on the cancer survival dataset is listed below.

Running the example first fits the model on the training dataset, then reports the classification accuracy on the test dataset.

Kick-start your project with my new book Data Preparation for Machine Learning, including step-by-step tutorials and the Python source code files for all examples.

In this case we can see that the model performs better than a no-skill model, given that the accuracy is above about 73.5%.

Accuracy: 0.765

Line plots of the loss on the train and test sets are then created.

We can see that the model quickly finds a good fit on the dataset and does not appear to be over or underfitting.

Learning Curves of Simple Multilayer Perceptron on Cancer Survival Dataset

Now that we have some idea of the learning dynamics for a simple MLP model on the dataset, we can look at developing a more robust evaluation of model performance on the dataset.

Robust Model Evaluation

The k-fold cross-validation procedure can provide a more reliable estimate of MLP performance, although it can be very slow.

This is because k models must be fit and evaluated. This is not a problem when the dataset size is small, such as the cancer survival dataset.

We can use the StratifiedKFold class and enumerate each fold manually, fit the model, evaluate it, and then report the mean of the evaluation scores at the end of the procedure.

...
# prepare cross validation
kfold = KFold(10)
# enumerate splits
scores = list()
for train_ix, test_ix in kfold.split(X, y):
# fit and evaluate the model...
...
...
# summarize all scores
print('Mean Accuracy: %.3f (%.3f)' % (mean(scores), std(scores)))

We can use this framework to develop a reliable estimate of MLP model performance with our base configuration, and even with a range of different data preparations, model architectures, and learning configurations.

It is important that we first developed an understanding of the learning dynamics of the model on the dataset in the previous section before using k-fold cross-validation to estimate the performance. If we started to tune the model directly, we might get good results, but if not, we might have no idea of why, e.g. that the model was over or under fitting.

If we make large changes to the model again, it is a good idea to go back and confirm that the model is converging appropriately.

The complete example of this framework to evaluate the base MLP model from the previous section is listed below.

Running the example reports the model performance each iteration of the evaluation procedure and reports the mean and standard deviation of classification accuracy at the end of the run.

Kick-start your project with my new book Data Preparation for Machine Learning, including step-by-step tutorials and the Python source code files for all examples.

In this case, we can see that the MLP model achieved a mean accuracy of about 75.2 percent, which is pretty close to our rough estimate in the previous section.

This confirms our expectation that the base model configuration may work better than a naive model for this dataset

Is this a good result?

In fact, this is a challenging classification problem and achieving a score above about 74.5% is good.

Next, let’s look at how we might fit a final model and use it to make predictions.

Final Model and Make Predictions

Once we choose a model configuration, we can train a final model on all available data and use it to make predictions on new data.

In this case, we will use the model with dropout and a small batch size as our final model.

We can prepare the data and fit the model as before, although on the entire dataset instead of a training subset of the dataset.

We can then use this model to make predictions on new data.

First, we can define a row of new data.

Note: I took this row from the first row of the dataset and the expected label is a ‘1’.

We can then make a prediction.

...
# make prediction
yhat = model.predict_classes([row])

Then invert the transform on the prediction, so we can use or interpret the result in the correct label (which is just an integer for this dataset).

And in this case, we will simply report the prediction.

Tying this all together, the complete example of fitting a final model for the haberman dataset and using it to make a prediction on new data is listed below.

Summary

In this tutorial, you discovered how to develop a Multilayer Perceptron neural network model for the cancer survival binary classification dataset.

Specifically, you learned:

  • How to load and summarize the cancer survival dataset and use the results to suggest data preparations and model configurations to use.
  • How to explore the learning dynamics of simple MLP models on the dataset.
  • How to develop robust estimates of model performance, tune model performance and make predictions on new data.

This article has been published from the source link without modifications to the text. Only the headline has been changed.

Source link